Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome.
Identifieur interne : 005453 ( Main/Exploration ); précédent : 005452; suivant : 005454Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome.
Auteurs : Margaret H L. Ng [République populaire de Chine] ; Kin-Mang Lau ; Libby Li ; Suk-Hang Cheng ; Wing Y. Chan ; Pak K. Hui ; Benny Zee ; Chi-Bon Leung ; Joseph J Y. SungSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antigènes HLA-B (génétique), Antigènes HLA-DR (génétique), Chaines HLA-DRB1, Dépistage génétique, Femelle, Fréquence d'allèle, Génotype, Humains, Indice de gravité médicale, Mâle, Prédisposition génétique à une maladie, Sujet âgé, Susceptibilité à une maladie, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (physiopathologie), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Antigènes HLA-B, Antigènes HLA-DR, Syndrome respiratoire aigu sévère.
- immunologie : Syndrome respiratoire aigu sévère.
- pathogénicité : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Chaines HLA-DRB1, Dépistage génétique, Femelle, Fréquence d'allèle, Génotype, Humains, Indice de gravité médicale, Mâle, Prédisposition génétique à une maladie, Sujet âgé, Susceptibilité à une maladie.
English descriptors
- KwdEn :
- Adult, Aged, Disease Susceptibility, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Testing, Genotype, HLA-B Antigens (genetics), HLA-DR Antigens (genetics), HLA-DRB1 Chains, Humans, Male, Middle Aged, SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Severity of Illness Index.
- MESH :
- chemical , genetics : HLA-B Antigens, HLA-DR Antigens.
- genetics : Severe Acute Respiratory Syndrome.
- immunology : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- Adult, Aged, Disease Susceptibility, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Testing, Genotype, HLA-DRB1 Chains, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P=.00008 [after Bonferroni correction, P<.0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%-19.0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.
DOI: 10.1086/421523
PubMed: 15243926
Affiliations:
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Chan</name></author><author><name sortKey="Hui, Pak K" sort="Hui, Pak K" uniqKey="Hui P" first="Pak K" last="Hui">Pak K. Hui</name></author><author><name sortKey="Zee, Benny" sort="Zee, Benny" uniqKey="Zee B" first="Benny" last="Zee">Benny Zee</name></author><author><name sortKey="Leung, Chi Bon" sort="Leung, Chi Bon" uniqKey="Leung C" first="Chi-Bon" last="Leung">Chi-Bon Leung</name></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. 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By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P=.00008 [after Bonferroni correction, P<.0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%-19.0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Chan, Wing Y" sort="Chan, Wing Y" uniqKey="Chan W" first="Wing Y" last="Chan">Wing Y. Chan</name><name sortKey="Cheng, Suk Hang" sort="Cheng, Suk Hang" uniqKey="Cheng S" first="Suk-Hang" last="Cheng">Suk-Hang Cheng</name><name sortKey="Hui, Pak K" sort="Hui, Pak K" uniqKey="Hui P" first="Pak K" last="Hui">Pak K. Hui</name><name sortKey="Lau, Kin Mang" sort="Lau, Kin Mang" uniqKey="Lau K" first="Kin-Mang" last="Lau">Kin-Mang Lau</name><name sortKey="Leung, Chi Bon" sort="Leung, Chi Bon" uniqKey="Leung C" first="Chi-Bon" last="Leung">Chi-Bon Leung</name><name sortKey="Li, Libby" sort="Li, Libby" uniqKey="Li L" first="Libby" last="Li">Libby Li</name><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name><name sortKey="Zee, Benny" sort="Zee, Benny" uniqKey="Zee B" first="Benny" last="Zee">Benny Zee</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Ng, Margaret H L" sort="Ng, Margaret H L" uniqKey="Ng M" first="Margaret H L" last="Ng">Margaret H L. Ng</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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